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Journal of Pharmacology And Experimental Therapeutics, Vol. 71, Issue 3, 256-260, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE BIOLOGICAL ESTIMATION OF ERGOMETRINE

EDWIN J. DEBEER 1 and PAUL E. TULLAR 1

1 From The Burroughs Wellcome & Co. U. S. A. Experimental Research Laboratories, Tuckahoe, N. Y.

It was found that both the mydriatic and the hyperthermal effects produced by ergometrine in the rabbit are quantitatively related to the dose and thus either may serve as a basis for the quantitative estimation of this drug.

When both of these effects are considered simultaneously qualitative properties are acquired in addition. It is then possible to distinguish between the results produced by ergometrine and those of ergotoxine.

Effective doses of ergometrine were found to be less toxic than those of ergotoxine.

Using 16 rabbits for an assay, limits of error of about ± 20 per cent may be expected.

Submitted on January 11, 1941






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