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Journal of Pharmacology And Experimental Therapeutics, Vol. 71, Issue 3, 210-214, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

TOXICITY OF NAPHTHOQUINONES WITH VITAMIN K ACTIVITY IN MICE

MICHAEL B. SHIMKIN 1

1 From the National Cancer Institute, National Institute of Health, United States Public Health Service, Bethesda, Maryland

The acute and chronic toxicity of six naphthoquinones with vitamin K activity were studied in mice. The compounds at high doses are respiratory depressants and produce acute vascular congestion which is sufficient to cause hemorrhagic extravasation in the renal tubules and in the liver.

No weight loss, anemia, or morphologic changes were observed in mice which were injected subcutaneously with 4 to 18 mgm. of 2-methyl-1, 4-naphthoquinone during 3 to 6 weeks.

Submitted on July 24, 1940




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 Arch Intern MedHome page
H. R. BUTT, W. V. LEARY, and R. M. WILDER
DISEASES OF NUTRITION: REVIEW OF CERTAIN RECENT CONTRIBUTIONS
Arch Intern Med, February 1, 1942; 69(2): 277 - 343.
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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.