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Journal of Pharmacology And Experimental Therapeutics, Vol. 71, Issue 2, 178-186, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF BERBERINE ON MAMMALIAN HEARTS

CHANG-SHAW JANG 1

1 From the Department of Pharmacology, Oxford

1. The action of berberine and its interaction with acetylcholine were investigated on three mammalian heart preparations: the heart-lung prepararation, the isolated cat's heart and the isolated rabbit's and cat's auricles.

2. Berberine stimulates the heart and augments the coronary flow in small and moderate doses, in large doses it depresses the heart.

3. The cardioinhibitory action of acetylcholine is potentiated by small doses of berberine but antagonised by moderate and large doses. Doses of berberine which are antagonistic to acetylcholine are also antagonistic to pilocarpine but not to KCl.

Submitted on July 31, 1940






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Copyright © 1941 by the American Society for Pharmacology and Experimental Therapeutics.