THE ENZYMIC INACTIVATION OF SUBSTITUTED PHENYLPROPYL-(SYMPATHOMIMETIC)-AMINES

¹ From the Department of Physiology, University of Wisconsin Medical School, Madison

It has been shown that the inactivation of different sympathomimetic compounds by the action of amine oxidase or phenol oxidase is dependent on their molecular configuration.

Those phenylpropylamines having the amino group on the terminal carbon atom of the side chain were oxidised in the presence of amine oxidase and oxygen.

The compounds having one or two hydroxyl groups on the benzene ring were oxidised in the presence of phenol oxidase.

If the amino group was on the carbon atom adjacent to the terminal one, and the molecule contained no hydroxyl groups on the ring the compound was not inactivated by either system.

Evidence has been presented to support the concept that amine oxidase and phenol oxidase or similar systems determine the oral efficacy and the excretion of these chemicals, that is in general, the action and fate of these sympathomimetic amines in the body.

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