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Journal of Pharmacology And Experimental Therapeutics, Vol. 71, Issue 1, 52-58, 1941
Copyright © 1941 by American Society for Pharmacology and Experimental Therapeutics

CHEMOTHERAPEUTIC ACTIVITY OF N4-ACYLSULFANILHYDROXAMIDES

BETTYLEE HAMPIL 1, G. W. WEBSTER 1, and MAURICE L. MOORE 1

1 From the Medical-Research Division, Sharp and Dohme, Inc., Glenolden, Pa.

Fourteen members of a series of N4-acylsulfanilhydroxamides and four related compounds have been tested for chemotherapeutic activity. Three of the derivatives, n-valeryl, n-hexanoyl and n-heptanoyl, possess a high degree of efficacy in combating experimental streptococcal infections in mice. They have also been found to be effective against a strain of meningococcus.

Blood concentrations of N4-hexanoylsulfanilhydroxamide, sulfanilamide and sulfapyridine have been determined in mice and correlated with chemotherapeutic activity.

Submitted on October 10, 1940






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