JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 70, Issue 4, 440-449, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

ON THE BIOLOGICAL ASSAY OF THE OXYTOCIC ACTIVITY OF PITUITARY EXTRACT (POSTERIOR LOBE)

C. A. MORRELL 1, M. G. ALLMARK 1, and W. M. BACHINSKI 1

1 From the Laboratory of Hygiene, Department of Pensions and National Health, Ottawa, Canada

1. A method for the assay of the oxytocic principle in pituitary extract (posterior lobe) is described.

2. Eight strips of muscle from the uterus of one guinea-pig suspended in Van Dyke and Hastings' solution are used for the test.

3. Potencies are calculated in terms of a standard from regression lines computed on the basis of an all-or-none response.

4. Selection of guinea-pigs for the test is simplified since weight within wide limits and the stage in the oestrous cycle are not important. All guinea-pigs used gave satisfactory assays.

5. The average error of 26 individual assays was 5.98 ± 7.13 per cent.

6. The errors of each individual test may be computed independently.

7. The results from a number of samples assayed by this method are reported.

Submitted on September 5, 1940






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