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Journal of Pharmacology And Experimental Therapeutics, Vol. 70, Issue 4, 433-439, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

RATE OF DISAPPEARANCE OF PITUITARY GONADOTROPHIN FROM THE BLOOD OF RABBITS

J. M. ROBSON 1 and A. I. S. MACPHERSON 1

1 From the Department of Pharmacology, University of Edinburgh

Gonadotrophin from horse pituitaries was injected intravenously into rabbits, and the disappearance of the hormone from the blood and excretion in the urine determined.

Less than half of the injected amount could be detected in the serum within 6 hours, and only small amounts were present after 24 hours. Some 10 to 20 per cent of the injected hormone was recovered from the urine.

A similar experiment performed on a child with a meningocoele showed that the hormone rapidly disappeared from the serum and that little of it was excreted in the urine.

Submitted on September 3, 1940






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