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Journal of Pharmacology And Experimental Therapeutics, Vol. 70, Issue 4, 428-432, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF SULFANILAMIDE ON TISSUES OF COLD-BLOODED VERTEBRATES (FROG SKIN AND TURTLE HEART)

T. CUNLIFFE BARNES 1

1 Osborn Zoological Laboratory, Yale University

1. The electrical potential of frog skin measured through Ringer's solution and Ag-AgCl electrodes is not altered by 1 per cent sulfanilamide.

2. The oxygen consumption of frog skin is depressed about 40 per cent by 1 per cent sulfanilamide.

3. Neoprontosil and sulfamido-chrysoidin have no effect on the electrical potential or oxygen consumption of frog skin.

4. The excised auricles of the turtle are chronotropically and inotropically stimulated by 1 per cent sulfanilamide.

5. The oxygen consumption of slices of ventricle of the turtle heart is not affected by 1 per cent sulfanilamide.

Submitted on August 29, 1940






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