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Journal of Pharmacology And Experimental Therapeutics, Vol. 69, Issue 4, 365-374, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

THE ABSORPTION AND EXCRETION OF SULFAPYRIDINE AND OF SODIUM SULFAPYRIDINE IN MAN

HERMAN D. RATISH 1, ARNOLD DAVIDSON 1, and JESSE G. M. BULLOWA 1

1 From the Medical Service, Harlem Hospital, Department of Hospitals, New York City, and the Littauer Pneumonia Research Fund of New York University College of Medicine

Blood levels of 4 to 6 mgm. per 100 cc. or higher may be obtained within 2frac12 hours when sodium sulfapyridine is administered 5 grams statim and 1 gram every 4 hours day and night.

With sodium sulfapyridine less acetyl sulfapyridine is present in the blood than when sulfapyridine is given.

Sodium sulfapyridine, orally administered in the dose used, caused no gastrointestinal irritation other than nausea and vomiting.

Submitted on June 7, 1940






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