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Journal of Pharmacology And Experimental Therapeutics, Vol. 69, Issue 4, 355-358, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

A BIOLOGICAL ASSAY OF STILBESTROL

VIRGIL L. KOENIG 1 and R. G. GUSTAVSON 1

1 Department of Chemistry, University of Colorado

A comparative biological assay of Stilbestrol against crystalline estrone was made. The amounts necessary for the rat unit, i.e., the amount necessary to produce estrus in 50 per cent of a large group of castrate rats, was as follows: Single injection in oil for estrone, 3.0 gamma; for Stilbestrol, 0.95 gamma; and multiple injections, aqueous, for estrone, 0.92 gamma; for Stilbestrol, 0.62 gamma.

Submitted on May 15, 1940






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Copyright © 1940 by the American Society for Pharmacology and Experimental Therapeutics.