THE PULMONARY AND URINARY EXCRETION OF PARALDEHYDE IN NORMAL DOGS AND IN DOGS WITH LIVER DAMAGE

¹ From the John Sealy Memorial Research Laboratory and the Departments of Pharmacology and Pathological Chemistry, University of Texas Medical School, Galveston, Texas

Dogs were given paraldehyde by stomach tube, in doses of 1.0, 1.5, and 2.0 ml. per kilogram. Normal dogs excreted 11.1 to 28.0 per cent via the lungs, and 0.1 to 2.5 per cent via the kidneys. In paired experiments, using the same dogs before and after liver damage, the pulmonary excretion was always substantially greater after liver damage. The increased pulmonary excretion was due in some animals chiefly to an increased rate of excretion; in others it was due chiefly to a prolonged time of excretion.

Urinary excretion of paraldehyde was comparatively small both in normal dogs and in dogs with liver damage.

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