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Journal of Pharmacology And Experimental Therapeutics, Vol. 69, Issue 3, 229-235, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

THE ANESTHETIC ACTIVITY OF OPTICAL ANTIPODES II. THE ARABINOCHLORALOSES

THOMAS C. BUTLER 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

By reaction of chloral with d- and with l-arabinose, four isomeric arabinochloraloses (two pairs of antipodes) have been obtained.

The four compounds have been tested as anesthetics in mice. agr-l-Arabinochloralose is much more active than its antipode. beta-d-Arabinochloralose is somewhat more active than its antipode.

The significance of the unequal activity of the antipodes in relation to the theories of narcosis is discussed.

Submitted on May 16, 1940






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Copyright © 1940 by the American Society for Pharmacology and Experimental Therapeutics.