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Journal of Pharmacology And Experimental Therapeutics, Vol. 69, Issue 2, 149-155, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF VARIOUS STEROL DERIVATIVES ON THE BLOOD PRESSURE OF THE RAT

ARTHUR GROLLMAN 1, T. R. HARRISON 1, and J. R. WILLIAMS JR. 1

1 The Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University and the Department of Medicine, Vanderbilt Hospital

The administration of estradiol, testosterone, desoxycorticosterone, progesterone and diethylstilboestrol to normal rats induced in some animals an elevation of blood pressure to hypertensive levels. It is suggested that this hypertensive effect is due to renal injury since it could be abolished by the administration of renal extracts and since other evidence points to changes occurring in the kidney following the use of these substances. The occurrence of hypertension in certain cases of Cushing's disease or of the adreno-genital syndrome is attributed to the formation of abnormal steroid products. The naturally occurring adrenal cortical hormone was found to be devoid of the pressor and toxic effects observed following the injection of desoxycorticosterone.

Submitted on April 1, 1940




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