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1 From the Department of Pharmacology, Oxford
1. Antagonism between atropine and adrenaline was demonstrated in dog's leg and rabbit ear perfusions, and for the nictitating membrane and blood pressure of spinal cats. Atropine also caused dilatation of the spleen and of the small intestine and a fall of blood pressure in cats under ether. Hyoscine, in the experiments tried, showed no antagonism to adrenaline.
2. Atropine caused a partial paralysis of the cervical sympathetic in rabbit ear perfusions, and of the cervical and thoracic sympathetic in spinal cats.
3. No antagonism was found between atropine and pituitary (posterior lobe) extract in rabbit ear perfusions.
4. It is pointed out that atropine is related chemically to cocaine, and the action of atropine described resembles that of large concentrations of cocaine which inhibit the action of adrenaline.
Submitted on February 24, 1940
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