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Journal of Pharmacology And Experimental Therapeutics, Vol. 69, Issue 1, 89-102, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

THE COMPARATIVE THERAPEUTIC ACTIVITY OF SULFANILAMIDE, SULFAPYRIDINE AND DIAMINOSULFONE IN STREPTOCOCCUS INFECTIONS IN MICE

E. K. MARSHALL JR. 1, J. T. LITCHFIELD JR. 1, and H. J. WHITE 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University

A comparison of the therapeutic activity of sulfanilamide, sulfapyridine, and diaminosulfone in streptococcus infection in mice has been made by a method which eliminates to a large extent certain errors inherent in the methods in common usage. On the basis of Median Survival Blood Concentrations, the activity ratios are 1.00, 1.09 and 2.92 respectively. A description and discussion of the method used in the comparison is given.

Submitted on March 2, 1940






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