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Journal of Pharmacology And Experimental Therapeutics, Vol. 69, Issue 1, 76-80, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

THERAPEUTICS OF EXPERIMENTAL HYPERTENSION

ARTHUR GROLLMAN 1, T. R. HARRISON 1, and J. R. WILLIAMS JR. 1

1 From the Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University, and the Department of Medicine, Vanderbilt University

The effect of sodium nitrite, potassium thiocyanate, erythrol tetranitrate, Allium sativum, acetyl-beta-methylcholine, sodium chloride, and renal extract on the blood pressures of hypertensive rats was investigated. The blood pressure was reduced to normal levels following the administration of renal extract. None of the so-called "depressor" or "hypotensive" substances manifested an ability to reduce appreciably the blood pressure and their clinical value is thus questionable. The administration of a relatively large dose of sodium chloride did not markedly elevate the blood pressure.

Submitted on February 28, 1940




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Copyright © 1940 by the American Society for Pharmacology and Experimental Therapeutics.