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Journal of Pharmacology And Experimental Therapeutics, Vol. 68, Issue 4, 433-436, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

III. THE TOXIC ACTIONS OF SODIUM DIPHENYL HYDANTOINATE (DILANTIN) WHEN INJECTED INTRAPERITONEALLY AND INTRAVENOUSLY IN EXPERIMENTAL ANIMALS

CHARLES M. GRUBER 1, VICTOR G. HAURY 1, MILES E. DRAKE 1, F. S. DERR 1, L. R. FORCEY 1, and C. M. GRUBER JR. 1

1 Department of Pharmacology, Jefferson Medical College, Philadelphia, Penna.

1. The train of symptoms following the administration of sodium diphenyl-hydantoinate is described.

2. The intraperitoneal LD50 dose for sodium diphenyl-hydantoinate in white mice is 200 mgm. per kilogram. The CD50 dose is 76 mgm. per kilogram.

3. The intraperitoneal LD50 dose for albino rats is 280 mgm. per kilogram.

4. In rabbits the intravenous LD50 dose is 125 mgm. per kilogram body weight and the CD50 dose is 41 mgm. per kilogram.

5. In dogs the intravenous CD50 dose is 32 mgm. per kilogram body weight. The LD50 dose is about 90 mgm. per kilogram.

Submitted on October 23, 1939




This article has been cited by other articles:


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 Arch NeurolHome page
R. P. Bazemore and E. C. Zuckermann
On the Problem of Diphenylhydantoin-Induced Seizures: An Experimental Approach
Arch Neurol, October 1, 1974; 31(4): 243 - 249.
[Abstract] [PDF]


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