JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KOLMER, J. A.
Right arrow Articles by RULE, A. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by KOLMER, J. A.
Right arrow Articles by RULE, A. M.
Journal of Pharmacology And Experimental Therapeutics, Vol. 68, Issue 3, 406-412, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

THE THERAPEUTIC ACTIVITY OF SULFANILAMIDE AND ALLIED COMPOUNDS IN EXPERIMENTAL BRUCELLOSIS OF MICE

JOHN A. KOLMER 1 and ANNA M. RULE 1

1 From the Research Institute of Cutaneous Medicine and the Department of Bacteriology and Immunology of Temple University School of Medicine, Philadelphia, Pa.

As shown in table 7 all five of the compounds employed in the treatment of acute brucellosis of mice showed best therapeutic results in the case of the 160 infected with Br. abortus. Of the 160 infected with Br. melitensis, the compounds were much less effective while of the 80 infected with Br. suis, the therapeutic effects were nil insofar as survival was concerned although all appreciably prolonged the lives of the mice and especially in the case of sulfanilamide and sulfapyridine.

In the Br. abortus infections best results were observed with aldanil followed in order by sulfanilamide, neo-prontosil and sulfapyridine.

In the Br. melitensis infections best results were observed with sulfapyridine followed in order by neo-prontosil and aldanil.

In the Br. suis infections best results were observed with sulfanilamide and sulfapyridine followed in order by neo-prontosil and aldanil.

It is apparent, therefore, that sulfanilamide, sulfapyridine, neo-prontosil and aldanil vary in their therapeutic effectiveness in the treatment of acute brucellosis of mice according to the strain of Brucella employed.

According to these results the compounds of choice in the treatment of undulant fever of human beings due to Br. abortus would appear to be aldanil, sulfanilamide, neo-prontosil and sulfapyridine in the order mentioned; for infections due to Br. melitensis, sulfapyridine and neo-prontosil while for those due to Br. suis, sulfanilamide, sulfapyridine, neo-prontosil and aldanil in the order given.

Submitted on December 11, 1939




This article has been cited by other articles:


Home page
 Arch Intern MedHome page
J. A. KOLMER
PROGRESS IN CHEMOTHERAPY OF BACTERIAL AND OTHER DISEASES: WITH SPECIAL REFERENCE TO THE PRONTOSILS, SULFANILAMIDE AND SULFAPYRIDINE
Arch Intern Med, April 1, 1940; 65(4): 671 - 743.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1940 by the American Society for Pharmacology and Experimental Therapeutics.