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Journal of Pharmacology And Experimental Therapeutics, Vol. 68, Issue 2, 278-283, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLIC FATE OF N-SUBSTITUTED DERIVATIVES OF BARBITAL

MILTON T. BUSH 1 and THOMAS C. BUTLER 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

A number of N-substituted derivatives of barbital have been prepared. Two of them, iso-propyl- and iso-butyl-(footnote 1), appear to be new compounds.

By isolation of barbital from the urine of dogs, it has been shown that N-dealkylation occurs to a large extent with the methyl and ethyl derivatives. No more than traces of barbital are excreted in the urine after administration of n-propyl-, iso-propyl-, allyl-, n-butyl-, and phenyl-barbital.

The effects on mice of these compounds, as well as of iso-butyl- and of sec-butyl-barbital are described.

Submitted on October 26, 1939






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