THE PHARMACOLOGY OF CERTAIN FURFURYL AND TETRA-HYDRO-FURFURYL AMMONIUM IODIDES

¹ From the Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania

1. In animals furfuryl trimethyl (F.T.M.), furfuryl dimethyl ethyl (F.D.M.E.), tetrahydro-furfuryl trimethyl (T.F.T.M.) and tetrahydro-furfuryl dimethyl ethyl (T.F.D.M.E.) ammonium iodides were found to be stable in blood, to produce a marked fall of blood pressure, cardiac inhibition and depression, an increased flow of saliva, and an increased tone of intestine and bladder. These effects are overcome or prevented by atropine.

2. Furfuryl dimethyl isopropyl (F.D.M.i-P), furfuryl dimethyl-normal propyl (F.D.M.n-P), furfuryl dimethyl normal butyl (F.D.M.n-B) and furfuryl dimethyl-normal amyl (F.D.M.n-A) ammonium iodides were found to have a complex and variable vascular action.

3. The depressor activity by intravenous injection in etherized cats was of the order F.T.M. > F.D.M.E. > T.F.T.M. > T.F.D.M.E. > F.D.M.i-P> F.D.M.n-P = F.D.M.n-B. = F.D.M.n-A.

4. The subcutaneous toxicity for rats was of the following order F.T.M. = T.F.T.M. > F.D.M.E. > T.F.D.M.E.

5. The subcutaneous and oral cathartic potency showed F.T.M. > T.F.T.M. > F.D.M.E. > T.F.D.M.E.

6. Evidence has been obtained that saturation of the furane ring of F.T.M. and F.D.M.E. decreased their parasympathomimetic potency but did not cause a corresponding decrease in toxicity.

7. In comparison with F.T.M. the miotic activity of T.F.T.M. is less in proportion to its depressor, cathartic, salivary and cardiac potency.

8. When compared with F.T.M. the cathartic potency of F.D.M.E. is less in proportion to its depressor, cardiac and miotic activity.

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