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Journal of Pharmacology And Experimental Therapeutics, Vol. 68, Issue 1, 69-72, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

SOME TETRAHYDROISOQUINOLINES A NOTE ON THE RELATIVE LETHAL AND CIRCULATORY EFFECTS OF SOME 2-ALKYL DERIVATIVES

AXEL M. HJORT 1, EDWIN J. DEBEER 1, and DAVID W. FASSETT 1

1 From The Burroughs Wellcome & Co. U.S.A. Experimental Research Laboratories, Tuckahoe, N. Y.

1. A series of 2-alkyl-1,2,3,4-tetrahydroisoquinoline homologs containing the normal arrangement of carbon atoms in the alkyl chain and another containing the iso-arrangement were tested for relative L 50 values in albino mice and for circulatory effects in atropinized, dial anesthetized dogs.

2. The L 50 values tend to decrease (increase in toxicity) with lengthening of the chain in the normal homologs but not to the degree found with homologous ureas. The iso-homologs showed no consistent trend with lengthening of the carbon chain.

3. These tetrahydroisoquinolines are essentially depressor in action.

Submitted on July 26, 1939




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