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Journal of Pharmacology And Experimental Therapeutics, Vol. 68, Issue 1, 36-40, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

II. THE EFFECT OF INTRAVENOUS INJECTIONS OF SODIUM DIPHENYL HYDANTOINATE (DILANTIN) ON RESPIRATION, BLOOD PRESSURE, AND THE VAGUS NERVE

VICTOR G. HAURY 1 and MILES E. DRAKE 1

1 From the Department of Pharmacology, The Jefferson Medical College, Philadelphia

1. Sodium diphenyl hydantoinate, "dilantin," when injected intravenously into dogs or rabbits produces a 31 to 65 per cent fall in blood pressure.

2. The action of this drug is peripheral in so far as the vascular system is concerned.

3. "Dilantin" has a depressant action on the vagus nerve.

4. "Dilantin," when given intravenously, has a marked depressant action on respiration.

5. Lethal doses of "dilantin" apparently produce a respiratory death.

Submitted on June 26, 1939






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