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Journal of Pharmacology And Experimental Therapeutics, Vol. 68, Issue 1, 123-129, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

THE TOXICITY OF LASIOCARPINE

K. K. CHEN 1, PAUL N. HARRIS 1, and HANS A. SCHULZE 1

1 From the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

Lasiocarpine in suitable amounts when injected intravenously in mice and rats causes delayed deaths. The principal lesion is necrosis of the liver. The distribution of necrotic areas varies—periportal, midzonal, or central. Extensive congestion of sinusoids and veins also occurs.

Lasiocarpine produces cloudy swelling of kidneys in the same animals.

Lasiocarpine has probably the same deleterious effect upon the liver and kidneys of guinea pigs.

Dogs receiving small daily doses of lasiocarpine (10 to 20 mgm. per kilogram) exhibit no pathological changes in the liver and kidney.

Lasiocarpine when given by vein has a depressor action in anesthetized cats. It has no influence upon the blood sugar of rabbits in sublethal doses when injected intravenously.

Submitted on August 3, 1939






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