JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 68, Issue 1, 104-112, 1940
Copyright © 1940 by American Society for Pharmacology and Experimental Therapeutics

SOME NEW ASPECTS OF MORPHINE ACTION EFFECTS ON PAIN

DONALD SLAUGHTER 1 and DONALD W. MUNSELL 1

1 From the Laboratory of Physiology and Pharmacology, Baylor Medical College, Dallas, Texas

1. Morphine effect is potentiated by Prostigmin when pressure-pain responses in the cat are determined.

2. Atropine antagonizes the effect of morphine or of a morphine-Prostigmin combination.

3. Evidence is presented to show that morphine fits many of the postulates necessary for a cholinergic drug.

4. Statistical analyses as to probability ("P") correlate well with result averages.

5. The mechanism of morphine action as an acetylcholine-like drug is discussed.

6. Practical application of these results is suggested.

Submitted on July 28, 1939






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