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Journal of Pharmacology And Experimental Therapeutics, Vol. 67, Issue 4, 429-436, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

THE PRODUCTION OF ANEMIA IN WHITE MICE BY SULFANILAMIDE, SULFAPYRIDINE AND DIAMINODIPHENYLSULFONE

ARTHUR P. RICHARDSON 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University

1. An anemia associated with a reticulocytosis has been produced in mice by feeding diets containing sulfanilamide, sulfapyridine and diaminodiphenylsulfone.

2. On the basis of minimal effective blood concentration which is necessary to produce a significant effect on the red cells of mice, sulfapyridine is one-half times as toxic as sulfanilamide, whereas diaminodiphenylsulfone is approximately twice as toxic as sulfanilamide.

Submitted on August 1, 1939




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Arch Intern Med, June 1, 1940; 65(6): 1211 - 1294.
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Copyright © 1939 by the American Society for Pharmacology and Experimental Therapeutics.