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Journal of Pharmacology And Experimental Therapeutics, Vol. 67, Issue 2, 175-186, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

FATE OF THE INJECTED OXYTOCIC PRINCIPLE OF POSTERIOR PITUITARY IN ANESTHETIZED CATS AND DOGS

EDWARD LARSON 1

1 Department of Pharmacology, School of Medicine, Temple University, Philadelphia, Pennsylvania

When an extract of 3 or 8 mgm. of pituitary powder per kilogram is injected intravenously into anesthetized cats or dogs, 30 per cent or less of the oxytocic principle is eliminated in the urine within two hours. These experiments also show that the oxytocic principle can be inactivated by the polypeptidases present in tissues.

Submitted on March 31, 1939






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Copyright © 1939 by the American Society for Pharmacology and Experimental Therapeutics.