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Journal of Pharmacology And Experimental Therapeutics, Vol. 66, Issue 4, 459-463, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF AMINOPYRIN AND ANTIPYRIN ON THE OXIDATION OF PHOSPHOLIPID BY VARIOUS TISSUES

FREDERICK BERNHEIM 1

1 From the Department of Physiology and Pharmacology, Duke University School of Medicine, Durham, North Caroline

1. Aminopyrin in a concentration of M/4500 inhibits the oxygen uptake of rat liver suspensions. Six to ten times the amount of antipyrin is without effect. The inhibition is greatest at pH 6.7.

2. The vanadium catalyzed oxidation of phospholipids by liver and bone marrow which is maximal at pH 6.7 is inhibited by aminopyrin but not by antipyrin. Other tissues show smaller vanadium effects but they react similarly to the two drugs.

Submitted on February 20, 1939






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Copyright © 1939 by the American Society for Pharmacology and Experimental Therapeutics.