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Journal of Pharmacology And Experimental Therapeutics, Vol. 66, Issue 2, 241-250, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

AN ANALYSIS OF THE RELATIONSHIPS BETWEEN ENVIRONMENTAL CHANGES AND THE DURATION OF ANESTHESIA IN ALBINO MICE

EDWIN J. DE BEER 1, AXEL M. HJORT 1, and DAVID W. FASSETT 1

1 From the Burroughs Wellcome and Co., U. S. A. Experimental Research Laboratories, Tuckahoe, New York

A statistical analysis was made of the influence of various factors on the duration of hypnosis in the albino mouse.

Over a period of about a year and a half, broad chronological subgroupings were found, lasting for months at a time, in which sleeping-times of similar length were observed.

No significant diurnal variations were encountered.

The length of sleeping-time was found to increase, in approximately linear fashion, with increased barometric pressure.

Shorter sleeping-times were experienced with higher wet-bulb or dry-bulb temperatures.

When the duration of hypnosis was less than about one hundred and ten minutes, shorter sleeping-times were associated with higher relative humidity values.

The existence of an association or relationship as determined above, does not imply cause and effect.

Submitted on December 3, 1938






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Copyright © 1939 by the American Society for Pharmacology and Experimental Therapeutics.