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Journal of Pharmacology And Experimental Therapeutics, Vol. 66, Issue 2, 206-215, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

STUDIES OF CYCLOPROPANE VII. AN ANALYSIS OF THE FACTORS CONTROLLING THE HEART RATE IN DOGS ANESTHETIZED WITH CYCLOPROPANE OR ETHER AFTER PREMEDICATION WITH MORPHINE

BENJAMIN H. ROBBINS 1, O. GARTH FITZHUGH 1, and JAMES H. BAXTER JR. 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

1. The effect of ether and cyclopropane anesthesia upon the bradycardia in dogs after medication with morphine has been investigated upon fifteen dogs, and the results show that: (a) ether causes an increase of the heart rate to a level as high as the control rate; (b) cyclopropane anesthesia maintains or augments the effect of morphine in slowing the heart.

2. The mechanisms by which ether and cyclopropane abolish or augment the effect of morphine upon the heart rate have been investigated upon six dogs which had progressive destruction of the autonomic paths to the heart. It was found that: (a) the tachycardia under ether anesthesia results from a depression of the vagal action and is not related to any extent to sympathetic stimulation; (b) the maintenance or augmentation of the morphine bradycardia with cyclopropane anesthesia is through an increase in vagal action.

Submitted on November 23, 1938




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B. H. ROBBINS
PREANESTHETIC MEDICATION
Arch Surg, June 1, 1940; 40(6): 1044 - 1056.
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Copyright © 1939 by the American Society for Pharmacology and Experimental Therapeutics.