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Journal of Pharmacology And Experimental Therapeutics, Vol. 66, Issue 1, 85-94, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF MAGNESIUM ON THE RESPONSE OF THE UTERUS TO POSTERIOR PITUITARY HORMONES

A. M. FRASER 1

1 From the Department of Pharmacology, McGill University, Montreal, Canada

1. Postlobin-V when compared with postlobin-O in van Dyke and Hastings' solution has an oxytocic activity four times as great as when compared similarly in ordinary Locke solution.

2. Magnesium chloride increases the response of the guinea pig uterus to both postlobin-O and postlobin-V, but the increase in response to the latter is much the greater.

3. The degree of oxytocic activity observed in an assay depends on the magnesium concentration of the uterine bath, when the ratio between oxytocic and pressor activities of the standard preparation is different from that of the unknown preparation.

4. Magnesium chloride decreases the uterine response to histamine and to ergobasine tartrate.

Submitted on October 17, 1938






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