THE LOCAL ANAESTHETIC ACTION OF CERTAIN PYRAZOLINE COMPOUNDS

¹ From the Departments of Pharmacology, Universities of Edinburgh and Lucknow

Derivatives of 1,5-di-phenyl-3-(-dialkylamino- or piperidinoethyl)-pyrazolines have been shown to have marked local anaesthetic properties. The anaesthetic activity is increased by increasing the size of the dialkylamino group and by the introduction of alkyl or alkoxy groups in the phenyl radicals at position 1 and 5. The toxicity is increased to a lesser degree by increasing the size of the dialkylamino group and by the introduction of alkoxy groups into the 1-phenyl radical. A decrease in toxicity follows the introduction of alkoxy groups in the 5-phenyl radical.