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Journal of Pharmacology And Experimental Therapeutics, Vol. 65, Issue 4, 424-439, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics


STUDIES OF PHENANTHRENE DERIVATIVES VIII. THE ACTION OF SOME PHENANTHRENE DERIVATIVES ON THE ISOLATED FROG HEART

ERWIN E. NELSON 1

1 From the Department of Materia Medica and Therapeutics, University of Michigan, and the Department of Pharmacology, Tulane University of Louisiana

A series of 15 nitrogen containing derivatives of phenanthrene has been studied with respect to its action on the isolated frog heart. The characteristic effect is a disturbance of ventricular rate, without modification of auricular rate. This disturbance, which resembles block, is not modified by atropine. Whether or not recovery is possible seems to be correlated with the structure of the particular compound studied.

Submitted on August 29, 1938







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Copyright © 1939 by the American Society for Pharmacology and Experimental Therapeutics.