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Journal of Pharmacology And Experimental Therapeutics, Vol. 65, Issue 4, 389-394, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

THE INHIBITION OF CHOLINE ESTERASE BY THIAMINE (VITAMIN B1)

DAVID GLICK 1 and WILLIAM ANTOPOL 1

1 From the Laboratories of the Newark Beth Israel Hospital, Newark, N. J.

The inhibition by thiamine of the choline esterase in horse and rat serum has been studied, and it was observed that inhibitions were obtained only with concentrations of thiamine in excess of those known at present to occur within living organisms.

The affinity of thiamine for choline esterase was calculated to be 26 times that of acetyl choline for the enzyme.

Submitted on July 23, 1938




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