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Journal of Pharmacology And Experimental Therapeutics, Vol. 65, Issue 2, 214-219, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

THE DISTRIBUTION OF ADMINISTERED BROMIDE IN COMPARISON WITH CHLORIDE AND ITS RELATION TO BODY FLUIDS

G. B. WALLACE 1, B. B. BRODIE 1, M. FRIEDMAN 1, and DAVID BRAND 1

1 From the Department of Pharmacology, New York University College of Medicine

1. The distribution of administered bromide in various tissues of body was determined and compared to that of chloride normally present.

2. It was found that wet tissue/serum ratios of bromide and chloride were in close agreement for all tissues except the brain, showing that these anions distribute in a similar manner in these tissues.

3. With the general acceptance of the evidence that chloride is distributed mainly, if not entirely, in extracellular fluid in inorganic form, it is concluded from our experiments that bromide is distributed in organs in like manner.

4. The similarity of distribution of chloride and bromide makes a selective chemical or physical relationship of the latter to tissue cells improbable.

Submitted on July 9, 1938






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Copyright © 1939 by the American Society for Pharmacology and Experimental Therapeutics.