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Journal of Pharmacology And Experimental Therapeutics, Vol. 65, Issue 2, 205-213, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLIC FATE OF N-METHYLBARBITURIC ACIDS

THOMAS C. BUTLER 1 and MILTON T. BUSH 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

After intravenous injections in dogs of anesthetic doses of N-methylbarbital, N-methylphenobarbital, and N,N'-dimethylbarbital there have been recovered from the urine considerable amounts of the corresponding 5,5-disubstituted barbituric acids. The significance of this demethylation with regard to the duration of action of N-methylbarbituric acids has been discussed.

Submitted on July 6, 1938






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Copyright © 1939 by the American Society for Pharmacology and Experimental Therapeutics.