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Journal of Pharmacology And Experimental Therapeutics, Vol. 65, Issue 2, 185-190, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF ANESTHESIA ON THE VASOMOTOR REVERSAL

ROBERT P. HERWICK 1, CHARLES R. LINEGAR 1, and THEODORE KOPPANYI 1

1 From the Department of Pharmacology and Materia Medica, Georgetown University, School of Medicine, Washington, D. C.

Ergotamine or ergotoxine in doses of 0.2 to 4.0 mgm. usually produces vasomotor reversal to epinephrine under urethane, but not under barbiturate anesthesia. In the latter the epinephrine pressor effects are usually increased in height and always in duration.

Large doses of atropine given before the ergot alkaloids in urethanized animals prevent the epinephrine reversal.

The mode of action of the anesthetic agents is discussed.

Submitted on June 30, 1938






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