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Journal of Pharmacology And Experimental Therapeutics, Vol. 65, Issue 2, 150-155, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

THE VASOCONSTRICTOR ACTION OF COCAINE

WILLIAM H. CROSBY 1

1 Laboratory of Pharmacology, University of Pennsylvania

The ability of cocaine to constrict the conjunctival and aural vessels of rabbits is not due to a potentiation of the vasoconstrictor action of adrenalin.

Experiments involving interruption of the sympathetic pathways at various points and experiments with ergotoxine suggest that the site of action of cocaine is a dual one involving 1) a sensitization of the smooth muscle of the blood vessel wall to tonic sympathetic discharges and 2) an adrenalin-like action upon the sympathetic receptors of the muscle cell.

Submitted on June 18, 1938




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