JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 65, Issue 2, 143-149, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

INFLUENCE OF CERTAIN METALS ON THE STABILITY OF INSULIN

MELVILLE SAHYUN 1, ARTHUR NIXON 1, and M. GOODELL 1

1 From the Biochemical Research Laboratory, Frederick Stearns and Company, Detroit, Michigan

Small amounts of zinc, in the ratio of 0.05, 0.1 and 0.4 mgm. to 1000 units, were shown to retard the rate of deterioration of low-ash, zinc-free insulin incubated at 52°C.

The addition of 1 mgm. of either cobalt, nickel or aluminum to 1000 units of insulin was observed to be very effective in preserving the physiologic activity of insulin incubated at 52°C. for at least seven weeks.

Submitted on June 16, 1938






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Copyright © 1939 by the American Society for Pharmacology and Experimental Therapeutics.