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Journal of Pharmacology And Experimental Therapeutics, Vol. 65, Issue 1, 61-69, 1939
Copyright © 1939 by American Society for Pharmacology and Experimental Therapeutics

AN ANALYSIS OF SEASONAL INFLUENCES ON THE DURATION OF ANESTHESIA IN ALBINO MICE

EDWIN J. DEBEER 1, AXEL M. HJORT 1, and CHARLES A. COOK 1

1 From the Burroughs Wellcome & Co. U. S. A. Experimental Research Laboratories, Tuckahoe, New York

A statistical analysis of the duration of anesthesia caused by different doses of n-propyl-o-tolyl urea and sodium ethyl-n-hexylbarbiturate showed that the data were symmetrically distributed except for the lower doses of the barbiturate, that the relative degree of dispersion was more constant with the urea compound, and that variations between results obtained at different times of the year were significantly greater than would be expected from chance alone.

Some practical applications of these findings are discussed.

Submitted on May 7, 1938






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Copyright © 1939 by the American Society for Pharmacology and Experimental Therapeutics.