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Journal of Pharmacology And Experimental Therapeutics, Vol. 64, Issue 4, 458-464, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

VARIATIONS IN THE ARGINASE CONCENTRATIONS IN THE LIVERS OF WHITE RATS CAUSED BY THE ADMINISTRATION OF ARSENIC AND LEAD

HOWARD D. LIGHTBODY 1 and HERBERT O. CALVERY 1

1 Division of Pharmacology, Food and Drug Administration, Department of Agriculture, Washington, D. C.

The arginase concentrations in the livers of white rats given lead or arsenic intraperitoneally in daily subacute doses are less than those found in untreated animals. Rats that ingested daily small quantities of lead mixed with the food were found to be unable to respond to prolonged fast by increases in the liver arginase concentration. The livers of suckling rats whose mothers were fed diets containing small quantities of arsenic and lead were found to contain less arginase at the time of opening of the eyes than did those suckled by mothers fed a control diet.

Submitted on May 16, 1938






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