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Journal of Pharmacology And Experimental Therapeutics, Vol. 64, Issue 4, 388-410, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF LEAD ON RATS FED DIETS CONTAINING LEAD ARSENATE AND LEAD ACETATE

EDWIN P. LAUG 1 and HAROLD P. MORRIS 1

1 Division of Pharmacology, Food and Drug Administration, United States Department of Agriculture, Washington, D. C.

1. A diet adequate in all the known food constituents necessary for growth and reproduction of the rat has been prepared. This diet was designed particularly for the study of the chronic toxicity of lead and arsenic at low levels and contained, on the average, from 0.61 to 0.73 mgm. of lead and 0.1 mgm. of arsenic per kilogram.

2. One kilogram of this diet containing 0.73 mgm. of lead was fed to each of 14 control animals whose paired litter mates were each fed the same quantity of the same diet containing 3.53 mgm. of lead. The added lead was in the form of lead arsenate.

3. The rate of growth of 9 experimental male rats was definitely less than that of their litter mate controls. No significant difference between control and experimental animals was observed in the rate of growth of 5 pairs of females.

4. The storage of lead was determined in the organs of 5 pairs, and the total storage in 10 pairs of animals. In the femurs, liver, kidneys, brain, hair, and total animal, the storage was significantly greater in the experimental than in the control animals.

5. Rats ingesting lead at a daily rate of 213 mgm. per kilogram of body weight (series B) showed slightly reduced growth rates. This was more marked in males than in females.

6. Lead ingestion over a period of 6 to 7 weeks at the rate of 213 mgm. per kilogram of body weight caused marked increase in the weights of the kidneys and spleen which paralleled roughly the lead storage in those organs.

7. Weekly balance studies on ingested lead are presented.

8. In a complete balance experiment, recovery of the lead averaged 98.2 per cent.

9. Lead analyses of series B animals were made of representative organs and of the total animal. These animals were paired litter mates, one of each pair being fed a control diet, the other the same diet with added lead.

10. A greater storage of lead was found per animal in 10 control rats fed for 84 days a diet containing 0.73 mgm. per kilogram than was found in 15 control rats fed for 50 days a similar diet containing 0.61 mgm. of lead per kilogram.

Submitted on March 28, 1938






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Copyright © 1938 by the American Society for Pharmacology and Experimental Therapeutics.