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Journal of Pharmacology And Experimental Therapeutics, Vol. 64, Issue 4, 355-363, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF ROOM TEMPERATURE ON THE ACTION OF BARBITURATES

J. RAVENTÓS 1

1 From the Department of Pharmacology, University of Edinburgh

1. The duration of action of sodium evipan on mice (3 x h.d.50 given intraperitoneally) is dependent on the room temperature (Dur. 20°C./Dur.30°C. = 2.4).

2. The l.d.50 of phenobarbitone at 20°C. is about frac23 that at 30°C.

3. Comparisons between the biological properties of barbiturate compounds should be carried out at a uniform room temperature and 30°C. seems preferable to 20°C.

Submitted on March 3, 1938




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Copyright © 1938 by the American Society for Pharmacology and Experimental Therapeutics.