JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by WISE, B.
Right arrow Articles by HOFF, H. E.
Right arrow Search for Related Content
PubMed
Right arrow Articles by WISE, B.
Right arrow Articles by HOFF, H. E.
Journal of Pharmacology And Experimental Therapeutics, Vol. 64, Issue 2, 217-224, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF THE AUTONOMIC HORMONES ON THE THYROTOXIC HEART

BOWMAN WISE 1 and H. E. HOFF 1

1 Laboratory of Physiology, Yale University School of Medicine

1. The effect of administration of Mecholyl and of adrenalin on the normal and on the thyrotoxic heart has been studied.

2. The response of the normal and of the thyrotoxic heart to administration of Mecholyl and of adrenalin is an entirely physiological one, in which an attempt is made through the cardiac reflexes to adjust the disturbed autonomic balance in the cardiovascular system. The response of the thyrotoxic heart to these substances is greatly exaggerated as compared to that of the normal heart.

3. The response of the thyrotoxic heart to the administration of the autonomic hormones is considered to be due in part to augmentation of the effect of existing acetyl-cholin and sympathin in the thyrotoxic heart. It is also considered that evidence has been obtained of the existence in the thyrotoxic heart of increased sensitivity to each of these substances.

Submitted on March 18, 1938






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1938 by the American Society for Pharmacology and Experimental Therapeutics.