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Journal of Pharmacology And Experimental Therapeutics, Vol. 64, Issue 2, 209-216, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

THE HYDROLYSIS OF HOMATROPINE AND ATROPINE BY VARIOUS TISSUES

FREDERICK BERNHEIM 1 and MARY L. C. BERNHEIM 1

1 From The Departments of Physiology and Pharmacology and Biochemistry Duke University School of Medicine, Durham, North Carolina

1. The liver of the guinea pig contains an esterase which will hydrolyze homatropine and atropine. The liver of the rat, cat and dog can hydrolyze these drugs very slowly, but the brain, kidney and blood are not active. Rabbit liver and serum usually contain an active enzyme but in approximately one out of every three animals these tissues are inactive.

2. All tissues which hydrolyze these drugs will also hydrolyze ethyl mandelate, but the latter is also hydrolyzed by tissues which are unable to attack homatropine and atropine.

3. Homatropine is always hydrolyzed more rapidly than atropine. The l-isomers of both drugs are preferentially attacked. Scopolamine is hydrolyzed very slowly if at all.

4. The hydrolysis of homatropine and atropine is inhibited by small amounts of physostigmine but ethyl mandelate is not inhibited. Sodium fluoride inhibits equally the atropines and ethyl mandelate.

5. The significance of these results is discussed.

Submitted on March 14, 1938






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Copyright © 1938 by the American Society for Pharmacology and Experimental Therapeutics.