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Journal of Pharmacology And Experimental Therapeutics, Vol. 64, Issue 2, 131-137, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

EXPERIMENTS WITH AN "ANTINECROTIC" MATERIAL PREPARED FROM LIVER

H. M. BARRETT 1, D. L. MACLEAN 1, and E. W. McHENRY 1

1 The School of Hygiene, University of Toronto

An investigation of the effect of the "antinecrotic" material of Forbes, Neale and Scherer, and of pure sodium xanthine, on rats which were exposed to controlled concentrations of carbon tetrachloride vapour has been made. With a high dose (12,000 to 13,000 p.p.m.) of carbon tetrachloride the protection afforded livers of rats was less marked than was obtained with a lower dose (7000 to 10,000 p.p.m.). The dosage of sodium xanthine or liver extract was 100 mgm. of material per animal in both cases.

Forbes, Neale and Scherer's results were corroborated when the dosage of carbon tetrachloride was between 7000 and 10,000 p.p.m.

Following exposure to carbon tetrachloride vapour the fat content of the livers of rats treated with sodium xanthine or liver extract was found to differ significantly from that of the livers of saline injected controls. Both the histological sections and the amounts of fat present in the liver indicated that sodium xanthine accelerated the healing of liver tissue in rats after carbon tetrachloride poisoning in addition to protecting the liver from damage.

Submitted on November 29, 1937






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