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Journal of Pharmacology And Experimental Therapeutics, Vol. 64, Issue 1, 58-64, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

THE BRONCHIO-DILATOR ACTION OF MAGNESIUM AND ITS ANTAGONISTIC ACTION (DILATOR ACTION) AGAINST PILOCARPINE, HISTAMINE AND BARIUM CHLORIDE

VICTOR G. HAURY 1

1 From the Department of Pharmacology, Jefferson Medical College, Philadelphia, Pennsylvania

1. The bronchodilator action of magnesium was determined by perfusion experiments on excised guinea pig lungs. Histamine, pilocarpine and barium chloride were used as bronchoconstrictor agents.

2. Histamine produced an average decrease in perfusion rate (constriction) of 82 per cent. Histamine plus magnesium produced a constriction of only 33 per cent.

3. Pilocarpine decreased the perfusion rate by 55 per cent whereas pilocarpine plus magnesium produced a dilation of 27 per cent.

4. Magnesium decreases the recovery time from barium constriction by 75 per cent.

5. Magnesium sulfate injected into a fresh unused lung or into a lung which has previously recovered from a constrictor drug, produces a bronchodilation of from 20 to 45 per cent.

Submitted on March 19, 1938




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Copyright © 1938 by the American Society for Pharmacology and Experimental Therapeutics.