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Journal of Pharmacology And Experimental Therapeutics, Vol. 63, Issue 3, 335-339, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

ON THE REPORTED ANEMIA-PRODUCING QUALITIES OF 1-METHYL-5-utri'-CYCLOHEXENYL-5-METHYL-BARBITURIC ACID (EVIPAN, EVIPAL)

HENRY K. BEECHER 1

1 From the Surgical Laboratories of the Harvard Medical School at the Massachusetts General Hospital, Boston, Massachusetts

Three dogs have been subjected to repeated "evipal" anesthesia, one at weekly intervals, one at two-weekly intervals and another at four-weekly intervals, all over a five-month period. Detailed studies of the erythrocyte count, the cell volume, the mean corpuscular volume, the hemoglobin and the oxygen capacity do not reveal any anemia producing effect of "evipal" in these dogs. This is contrary to other published accounts.

Submitted on December 13, 1937






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Copyright © 1938 by the American Society for Pharmacology and Experimental Therapeutics.