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Journal of Pharmacology And Experimental Therapeutics, Vol. 63, Issue 3, 215-228, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

THE IRRITABILITY OF THE CARDIAC VAGUS NERVES AS INFLUENCED BY THE INTRAVENOUS INJECTIONS OF BARBITURATES, THIO-BARBITURATES AND PICROTOXIN

CHARLES M. GRUBER 1, CHARLES M. GRUBER JR. 1, and NICHOLAS A. COLOSI 1

1 From the Department of Pharmacology, Jefferson Medical College, Philadelphia, Pennsylvania

1. All of the barbiturates studied in this investigation (evipal sodium, sodium pentobarbital, ortal sodium and sodium amytal) depressed the cardiac vagus nerves.

2. Pentothal sodium, sodium thio-ethamyl and sodium thiopentobarbital may increase the responsiveness of the heart to vagus nerve stimulation.

3. In some experimental animals picrotoxin antagonizes the cardiac vagus depressant action of the barbiturates (evipal, pentobarbital and ortal).

Submitted on November 15, 1937






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