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Journal of Pharmacology And Experimental Therapeutics, Vol. 63, Issue 1, 58-64, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

COLLOIDAL URANIUM

I. TOXICITY

A. H. MALONEY 1 and A. F. BURTON 1

1 Department of Pharmacology, Howard University School of Medicine, Washington, D. C.

The gross toxic effects of colloidal uranium are studied in the light of the known actions of uranium nitrate:

1. In doses of 1 mgm. per kilogram administered at intervals of ten minutes five or six times, colloidal uranium exerts no significant effect on the blood pressure or respiration.

2. Administered in daily doses of 1 mgm. per kilogram to kittens it produces a gradual weight loss leading to death within three weeks to one month.

3. As a rule animals can tolerate a single dose of 1 to 5 mgm. per kilogram. This was found to be the case with mice, guinea pigs, kittens and cats.

4. Colloidal uranium is distinctly less toxic than uranium nitrate to the organism as a whole.

Submitted on October 1, 1937






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