JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SMITH, P. K.
Right arrow Search for Related Content
PubMed
Right arrow Articles by SMITH, P. K.
Journal of Pharmacology And Experimental Therapeutics, Vol. 62, Issue 3, 467-474, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

THE RELATION OF ACETANILID AND OTHER DRUGS TO ANALGESIA IN MONKEYS

PAUL K. SMITH 1

1 From the Laboratory of Pharmacology and Toxicology, Yale University School of Medicine, New Haven, Connecticut

Methods have been adapted for studying in monkeys the effects of analgesics by their ability to increase the alternating current voltage or the weight on a needle required to produce a sudden respiratory change probably associated with pain.

Insofar as these methods are criteria of pain, acetanilid in a dose of 100 mgm. per kilogram and morphine, in a dose of 10 mgm. per kilogram, have been demonstrated to be effective analgesics in monkeys. With aspect to both time of maximum intensity and duration, analgesia and antipyresis were coincident. In the case of acetaniid, the analgesia is prevented by caffeine but uninfluenced by sodium bicarbonate.

Submitted on September 30, 1937






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1938 by the American Society for Pharmacology and Experimental Therapeutics.